CD47 - Explore an overview of CD47, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.
Search results for CD47 at Sigma-Aldrich. Summary: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.
12342-CD47. Antal rum. 4 rum varav 3 sovrum. Antal badrum. 2 energi solcellerna bidrar med. https://monitoringpublic.solaredge.com/solaredge-web/p/kiosk?guid=5e767757-cd47-41f5-809b-2124dc75ad7b&locale=sv_SE.
Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. CD47 is a protein complex composed of specific integrin, G protein, and cholesterol and is widely expressed on the surface of cell membrane. The ligand for CD47 is the SIRPα chain, a transmembrane protein, whose extracellular region contains three immunoglobulin superfamily-like regions and the N-terminal region mediates binding to CD47. CD47-Directed TTI-622 Elicits Early Efficacy Signals in Relapsed/Refractory Lymphoma Tissue distribution and regulation of CD47 and binding partners . Expression of CD47 in normal cells and cancer. CD47 is expressed on almost all normal human cells, as evaluated by mRNA expression and immunohistochemical staining, and occurs in four highly conserved isoforms that differ only in the length of their cytoplasmic domain, ranging from 3 to 36 amino acids (Reinhold et al., 1995).
CD47 (CD47 molecule) is a protein-coding gene.
When a cell senses an infectious agent with molecules called pathogen recognition receptors, part of its response is to increase cell surface expression of a molecule called CD47, otherwise known as the “don’t eat me” signal.
CD47 is expressed on almost all normal human cells, as evaluated by mRNA expression and immunohistochemical staining, and occurs in four highly conserved isoforms that differ only in the length of their cytoplasmic domain, ranging from 3 to 36 amino acids (Reinhold et al., 1995). cd47 (iap, mer6, oa3) Tissue specificity i The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA , GTEX and FANTOM5 . CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion.
Version: c454d025-cd47-4179-a88b-893ca24d3e69. Författare: Адміністратор сайту Коломия. Tidsstämpel: Juli 4, 2019, 07:55 (UTC). Loggmeddelande:.
CD47-Directed TTI-622 Elicits Early Efficacy Signals in Relapsed/Refractory Lymphoma Tissue distribution and regulation of CD47 and binding partners . Expression of CD47 in normal cells and cancer.
We originally identified increased expression of CD47 on AML stem cells, and subsequently identified high expression on many solid tumors including carcinomas, lymphomas, sarcomas, melanomas, and central nervous system tumors. 2021-03-16
CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity.
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25,26 Here we describe the recognition and uptake of aged erythrocytes through CD47-SIRPα interaction as a new mechanism for erythrocyte clearance. CD47, also known as integrin-associated protein (IAP), ovarian cancer antigen OA3, Rh-related antigen and MER6, is a multispanning transmembrane receptor belonging to the immunoglobulin superfamily that is important in self-recognition, cell adhesion and survival, immune regulation, and cardiovascular physiology. Leukozyten-Oberflächenantigen CD47 nach PDB 2JJS: Andere Namen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Leukocyte surface antigen CD47 Vorhandene Strukturdaten: PDB 2JJT, PDB 2VSC.
CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha . CD47 is a transmembrane glycoprotein, widely expressed in the large majority of human tissues, where it functions as a ligand for several receptors, including thrombospondin and signal regulatory protein alpha (SIRPα). From: Blood Cells, Molecules, and Diseases, 2015.
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Our next-generation anti-CD47 antibodies are highly differentiated, with the Importantly, AO-176 binds preferentially to CD47 on tumor cells, instead of normal
Validated in WB, IHC and tested in Human. Cited in 1 publication(s). Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. There are three CD47 antagonists in phase I clinical trials, but their TSP-1和CD47的結合還會影響許多基本的細胞活動，包括凋亡、增殖、黏著與遷移 ，亦對血管新生和免疫有調節作用。 信號調節蛋白α（SIRPα）[編輯].